Computational Analysis Suggests a New Hypothesis for Motor Learning in the Vestibulo-Ocular Reflex

Vestibulo-Ocular Reflex Abnormalities in Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo: A Pilot Study

Introduction: Benign paroxysmal positional vertigo (BPPV), involving the semicircular canals, is one of the most common diseases of the inner ear. The video head impulse test (vHIT) is a new test that examines the function of the canals. This study aimed to investigate the vestibulo-ocular reflex (VOR) gain, gain asymmetry and saccades after stimulating all six canals in patients definitively d...

A Recipe for Bidirectional Motor Learning: Using Inhibition to Cook Plasticity in the Vestibular Nuclei

In this issue of Neuron, McElvain et al. demonstrate for the first time plasticity at the synapse between vestibular nerve afferents and their postsynaptic targets in the medial vestibular nuclei. This new type of plasticity, which is gated by inhibition, is well suited to drive motor learning during adaptation of the vestibulo-ocular reflex.

Expression of a Protein Kinase C Inhibitor in Purkinje Cells Blocks Cerebellar LTD and Adaptation of the Vestibulo-Ocular Reflex

Cerebellar long-term depression (LTD) is a model system for neuronal information storage that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed to underlie several forms of cerebellar motor learning. Previous studies using various knockout mice (mGluR1, GluRdelta2, glial fibrillary acidic protein) have supported this claim; however, this work has suffered...

1 2 3 The bidirectionality of motor learning in the vestibulo - ocular reflex is a function of 4 cerebellar mGluR 1 receptors 5 6

Rapid motor learning in the translational vestibulo-ocular reflex.

Motor learning was induced in the translational vestibulo-ocular reflex (TVOR) when monkeys were repeatedly subjected to a brief (0.5 sec) head translation while they tried to maintain binocular fixation on a visual target for juice rewards. If the target was world-fixed, the initial eye speed of the TVOR gradually increased; if the target was head-fixed, the initial eye speed of the TVOR gradu...